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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC4
All Species:
31.52
Human Site:
S518
Identified Species:
43.33
UniProt:
Q9NTJ3
Number Species:
16
Phosphosite Substitution
Charge Score:
-0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NTJ3
NP_001002800.1
1288
147182
S518
S
R
H
N
T
A
V
S
Q
L
T
K
A
K
E
Chimpanzee
Pan troglodytes
XP_001157958
1288
147223
S518
S
R
H
N
T
A
V
S
Q
L
T
K
A
K
E
Rhesus Macaque
Macaca mulatta
XP_001099428
1287
147121
S517
S
C
H
N
T
A
V
S
Q
L
T
K
A
K
E
Dog
Lupus familis
XP_535848
1288
147094
S518
S
R
H
N
T
A
V
S
Q
L
N
K
A
K
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG47
1286
146876
S516
S
R
H
N
T
A
V
S
Q
L
S
K
A
K
E
Rat
Rattus norvegicus
Q9Z1M9
1233
143186
K475
R
R
I
D
E
I
N
K
E
L
N
Q
V
M
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510551
1069
122201
V365
E
A
K
S
S
L
A
V
N
R
S
R
G
K
V
Chicken
Gallus gallus
NP_989849
1274
145838
S489
T
R
Y
N
T
A
V
S
Q
L
D
E
A
K
E
Frog
Xenopus laevis
P50532
1290
146971
S512
S
R
H
N
S
A
L
S
Q
L
N
K
A
K
E
Zebra Danio
Brachydanio rerio
NP_775360
1289
145687
N517
S
Q
H
N
T
A
I
N
Q
L
N
Q
A
K
S
Tiger Blowfish
Takifugu rubipres
NP_001027927
1326
150958
T514
S
R
H
N
K
A
V
T
Q
L
N
S
A
K
Q
Fruit Fly
Dros. melanogaster
Q9VJE5
1690
189046
F769
A
Q
N
T
Q
K
D
F
E
L
V
E
S
G
E
Honey Bee
Apis mellifera
XP_396862
1282
148175
E454
S
I
E
S
T
E
K
E
K
L
E
K
L
K
H
Nematode Worm
Caenorhab. elegans
Q20060
1549
176553
D524
K
L
A
N
S
G
T
D
K
L
I
E
L
K
K
Sea Urchin
Strong. purpuratus
XP_797583
1289
146235
S518
K
E
L
N
E
A
K
S
Q
K
T
L
A
D
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJL0
1241
141112
K460
K
K
H
E
A
A
L
K
A
F
T
D
A
Q
K
Baker's Yeast
Sacchar. cerevisiae
Q12267
1418
162171
K591
E
T
Q
A
K
L
K
K
N
V
E
T
L
E
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.3
94
N.A.
89.5
24
N.A.
67.8
75.3
76.9
67.9
66.7
20.1
45.9
29.9
48.1
Protein Similarity:
100
99.6
98.9
96.5
N.A.
94.8
47.5
N.A.
75
86.3
87.5
83.5
81.2
40.2
63.9
47.5
65.4
P-Site Identity:
100
100
93.3
93.3
N.A.
93.3
20
N.A.
6.6
73.3
80
60
66.6
13.3
33.3
20
40
P-Site Similarity:
100
100
93.3
93.3
N.A.
100
40
N.A.
33.3
93.3
93.3
86.6
80
53.3
46.6
46.6
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.3
35.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
58.7
55.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
53.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
6
6
6
6
6
65
6
0
6
0
0
0
65
0
0
% A
% Cys:
0
6
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
6
0
0
6
6
0
0
6
6
0
6
0
% D
% Glu:
12
6
6
6
12
6
0
6
12
0
12
18
0
6
59
% E
% Phe:
0
0
0
0
0
0
0
6
0
6
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
6
0
0
0
0
0
0
6
6
0
% G
% His:
0
0
53
0
0
0
0
0
0
0
0
0
0
0
6
% H
% Ile:
0
6
6
0
0
6
6
0
0
0
6
0
0
0
0
% I
% Lys:
18
6
6
0
12
6
18
18
12
6
0
42
0
71
12
% K
% Leu:
0
6
6
0
0
12
12
0
0
77
0
6
18
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
6
0
% M
% Asn:
0
0
6
65
0
0
6
6
12
0
30
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
12
6
0
6
0
0
0
59
0
0
12
0
6
6
% Q
% Arg:
6
48
0
0
0
0
0
0
0
6
0
6
0
0
0
% R
% Ser:
53
0
0
12
18
0
0
48
0
0
12
6
6
0
12
% S
% Thr:
6
6
0
6
48
0
6
6
0
0
30
6
0
0
0
% T
% Val:
0
0
0
0
0
0
42
6
0
6
6
0
6
0
6
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
6
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _